Direct binding of aripiprazole‐LAMP2a prevented the HSC70‐mediated lysosomal degradation of RNH1 and inactivated RNH1/miR‐99a/mTOR signaling, thereby suppressing CRC tumorigenesis via autophagy‐mediated apoptosis (Figure 8). This evidence concerns the gene HSPA8 and colorectal carcinoma.