We then determined the sensitivity of several CRC cells with different levels of mTOR to aripiprazole (Figure S1A, Supporting Information) and found that aripiprazole had weaker effects on the inhibition of cell proliferation and the induction of apoptosis in RKO and NCM460 cells, which have lower mTOR expression (Figure S1B–D, Supporting Information). Here, MTOR is linked to colorectal carcinoma.