For example, everolimus, a rapamycin analog, has been used to treat cancer by suppressing mTOR signaling.[22, 23] In this study, we repurposed aripiprazole, an atypical antipsychotic drug, as an effective anticancer agent for CRC, which targets LAMP2a to induce RNH1/miR‐99a/mTOR‐mediated autophagy and subsequent apoptosis. The gene discussed is MTOR; the disease is colorectal carcinoma.