LAMP2a plays an important role in chaperone‐mediated autophagy (CMA),[11] a biological process involving the lysosomal degradation of proteins carrying a recognizable peptide sequence motif, KFERQ.[12, 13] The molecular chaperone heat shock cognate 71 kDa protein (HSC70) recognizes proteins bearing the motif and translocates them to lysosomes for degradation, via binding to LAMP2a.[14] CMA and LAMP2a are highly activated in various malignant tumors.[13, 15, 16]. The gene discussed is HSPA8; the disease is cancer.