IFNG and neoplasm: Profiling of the tumor immune microenvironment using the gene expression signatures developed by Danaher et al. (30) showed clustering of strongly immune infiltrated (mostly CM) and less immune infiltrated (mostly MucM) samples (Figure 3C) and significantly higher IFN-γ signature (23) levels in CM as compared with MucM tumors (P = 5.1 × 10–8, Figure 3C).