We read with great interest the recent study by Xie et al., which showed for the first time that Docking protein 1 (DOK1) has an undiscovered role in promoting the progression of clear cell renal cell carcinoma (ccRCC) via the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK3β) signaling axis 1. Here, GSK3B is linked to nonpapillary renal cell carcinoma.