Additionally, the biological function of DOK1 has been studied mainly in the hematopoietic system, and multiple studies have indicated that DOK1 is positively correlated with the oncogenesis of several hematopoietic malignancies, including chronic myelogenous leukemia (CML) 8, chronic lymphocytic leukemia (CLL) 9, histiocytic sarcoma 10, and Burkitt's lymphoma 11. Here, DOK1 is linked to B-cell chronic lymphocytic leukemia.