Qiu et al. found that the overexpression of CHI3L1 can intensify the proliferation, migration and invasion of HCC cells, and proposed a hypothesis that CHI3L1 may active TGF-β signaling pathway by binding to interleukin-13 receptor subunit α2 (IL-13Rα2) 23. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.