We also found that the tumor size (HR =1.61, 95% CI = 1.10-2.35, P = 0.013), the biomarker AFP (HR =1.70, 95% CI = 1.25-2.31, P < 0.001) and DCP (HR =1.67, 95% CI = 1.06-2.62, P = 0.026), and NLR (HR =2.07, 95% CI = 1.47-2.91, P < 0.001), INR (HR =1.58, 95% CI = 1.16-2.14, P = 0.003) were all independent prognostic factors for HCC survival. This evidence concerns the gene AFP and hepatocellular carcinoma.