To determine how EZH2 mediated CCL22-CCR4 expression through epigenetic regulation cause EMT remodeling in vivo, the levels of EZH2, H3K27me3, DNMT3A, EMT-related proteins and CCL22-CCR4 in xenograft tumor tissues were examined by western blotting or RT-qPCR. The gene discussed is DNMT3A; the disease is neoplasm.