Interestingly, cells treated with recombinant human CCL22 exhibited increased vimentin, slug, snail and β-catenin levels and decreased ZO-1 levels, neutralization with the CCL22 antibody caused the opposite effect (Fig. 4B), indicating CCL22 stimulation contribute CCR4-expressing cervical cancer cells EMT remodeling. The gene discussed is TJP1; the disease is cervical cancer.