It was found that both CEACAM1-4S and 4L overexpression could promote the invasive and metastatic ability of colon cancer cell line HT2925, 26, while the invasive and metastatic ability of hepatocellular carcinoma cell line HLF was impaired after overexpression of CEACAM1-4S and 4L27. This evidence concerns the gene CEACAM1 and colonic neoplasm.