SPAG5 and neoplasm: Furthermore, from the 44 overlapping genes having higher association with NDC80 complex components in the tumor context, we obtained the top 10 hub genes, including PCNA, CDK1, RFC4, SPAG5, SHCBP1, RNASEH2A, CCNB1, ZWINT, MCM3, and MCM6 (Figure 6G).