MAPT and early-onset autosomal dominant Alzheimer disease: With respect to episodic memory, deactivation of the DMN is thought to reflect the proper reallocation of neuronal resources necessary for successful encoding,88,89 while increased activation of the hippocampus supports the encoding of novel information but is suppressed during stimulus repetition.36,79,90 Moreover, the DMN and hippocampus are differentially related to Alzheimer’s disease pathology, whereby the former initially accumulates Aβ before being targeted by tau and the latter is far more susceptible to tau pathology.6,8,17,91