MAPT and early-onset autosomal dominant Alzheimer disease: For example, previous work has found that higher CSF p-tau181 is associated with hyperactivation in attentional control regions (i.e. parieto-frontal) during two different attention tasks37 and with hyperactivation in the hippocampus during mnemonic discrimination.34 These results support the general association between Alzheimer’s disease neuropathological change and hyperactivation, as current p-tau biomarkers may reflect both Aβ and non-aggregated forms of phosphorylated tau, particularly in cognitively normal populations.166