In lower animals such as Caenorhabditis elegans and flies, inhibition of insulin signaling has been shown to suppress aging and extend lifespan, but in mammals including humans, diabetes, a condition in which insulin action is impaired in metabolism, increases the risk of aging-related diseases such as atherosclerosis, cancer, dementia, and sarcopenia, and if the condition is not adequately controlled, life expectancy is also thought to be shortened (3). The gene discussed is INS; the disease is sarcopenia.