Previous studies have also found that ITPKB was an essential regulator of neuronal apoptosis and tau phosphorylation in Alzheimer’s disease, suggesting that ITPKB may be a novel target for mitigating pathological changes in AD (Stygelbout et al., 2014; Salta et al., 2016). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.