TLR4 and ischemia: It has been reported that eNAMPT triggers the Toll-like receptor 4/NOD-like receptor thermal protein domain associated protein three/interleukin 1β (TLR4/NLRP3/IL-1β) axis in the literature (Romacho et al., 2020), both NAMPT and SIRT1 protect the heart from ischemia/reperfusion.