AR and Hand-foot syndrome: AGA, a prevalent form of hair loss characterized by progressive follicular miniaturization, is attributed to the presence of androgens in genetically predisposed HFs in androgen-sensitive areas.[22] The pathogenesis of AGA has been found to be primarily related to androgen and AR signaling, with nuclear localization of AR being high in dermal papillae of the balding scalp of AGA patients.[23] If left untreated, the condition progresses gradually.[24] Despite the increasing prevalence of AGA, effective treatment modalities with minimal side effects are still lacking.