SOX2 and neuroendocrine neoplasm: Researchers have discovered that the inhibition of Exportin 1 effectively suppresses the upregulation of the transcription factor sex determining region Y-box 2(SOX2), which plays a critical role in neuroendocrine transformation and is overexpressed in SCLC transformation.[79] Additionally, it has been observed to enhance the effectiveness of standard chemotherapy in treating neuroendocrine tumors following histological transformation.[79]