EZH2 and non-small cell lung carcinoma: However, ABT-263 failed to induce a robust apoptotic response in resistant EGFR mutant NSCLC cell lines harboring the T790M resistance mutation, and the mechanisms behind this failure remain unknown.[52] Additionally, a study conducted by Gardner et al. highlighted the role of Schlafen family member 11 (SLFN11) suppression in acquired chemoresistance, which can be regulated by Enhancer of zeste homolog 2 (EZH2).