Thus, they inferred that EGFR T790M-positive ADC may be indirectly related to LCNEC transformation.[104] Generally, although LCNEC was resistant to chemotherapy, early evidence proved that subsequent carboplatin combined with etoposide therapy after osimertinib-resistant transformed LCNEC was efficient, which raising hopes for more personalized treatment.[104,106] However, little known about potential mechanisms and treatments have been proposed, as cases of LCNEC transformation were rare. Here, EGFR is linked to large cell neuroendocrine carcinoma.