K. Ishioka et al. demonstrated that the upregulation of fibroblast growth factor 9 (FGF9) in established ADC cells has a context-dependent effect.[72] Preclinical study conducted by Ferone et al. observed that FGFR1K656E and TP53F/F can modify the propensity of specific cell types to give rise to SCLC.[73] In an in vivo study, transformed SCLC-like tumors showed a successful response to the pan-FGFR inhibitor AZD4547. The gene discussed is FGF9; the disease is AIDS dementia complex.