Finally, another 20 proteins were upregulated in at least two cancer cell lines, with multiple proteins previously associated with resistance to HER2 targeted therapy including forkhead box protein M1 [27], ribonucleotide reductase M2 [28], signal transducer and activator of transcription 3 [8], ribosomal protein S6 [29], and fatty acid synthase [30]. This evidence concerns the gene STAT3 and cancer.