Currently, the main approach for treating heart failure is to improve hemodynamics by regulating the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS), which includes positive inotropy, diuresis, and vasodilation (Mullens et al., 2017; Wu and Vaseghi, 2020; Tang and Kiang, 2020). The gene discussed is REN; the disease is heart failure.