Its mechanism of action involves inhibiting neprilysin and angiotensin receptors, increasing the levels of atrial natriuretic peptide and angiotensin, enhancing renin activity, and exerting diuretic, blood pressure-lowering, and peripheral vasodilatory effects, thereby improving pathological remodeling of the damaged heart and relieving heart failure (Docherty et al., 2020; Aimo et al., 2022). Here, REN is linked to heart failure.