For example, HULC promotes survival and resistance to radiotherapy in prostate cancer by upregulating Beclin-1 and downregulating mTOR, while RHPN1-AS1 suppresses autophagy through miR-7-5p sponging and EGFR activation, highlighting the diverse regulatory roles of lncRNAs in autophagy depending on the cellular environment and specific mutations. This evidence concerns the gene RHPN1 and Familial prostate cancer.