For example, HULC promotes survival and resistance to radiotherapy in prostate cancer by upregulating Beclin-1 and downregulating mTOR, while RHPN1-AS1 suppresses autophagy through miR-7-5p sponging and EGFR activation, highlighting the diverse regulatory roles of lncRNAs in autophagy depending on the cellular environment and specific mutations. The gene discussed is HULC; the disease is Familial prostate cancer.