Using two different sets of ccRCC and AC serum samples, Wu and colleagues (Wu et al., 2016) investigated the expression of five different long non-coding RNAs (lncRNAs): lncRNA–low expression in tumor (LET), Plasmacytoma Variant Translocation 1 (PVT1), Promoter of CDKN1A Antisense DNA Damage Activated RNA (PANDAR), Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1), and long intergenic non-protein RNA 963 (linc00963). The gene discussed is PVT1; the disease is neoplasm.