Furthermore, PA successfully reversed hepatotoxicity in CCl4-induced hepatic fibrosis rats via the underlying mechanisms of regulating serum enzymes and attenuating TNF-α/NF-κB pathway for anti-inflammation response, as well as improving metabolic function in liver tissue, which might be one of the regulator mechanisms of antifibrosis (Li et al., 2013). The gene discussed is NFKB1; the disease is Hepatic fibrosis.