And it was found for the first time that ISL could inhibit Annexin A2 expression both in vivo and in vitro, block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway and regulate the expression of α-SMA by inhibiting the phosphorylation of STAT3 at the downstream signal to finally reverse HSCs activation and hepatic fibrosis (Liu et al., 2023). Here, ACTA1 is linked to Hepatic fibrosis.