TGFB1 and Hepatic fibrosis: It has been documented that HD (50, 100, 200 mg/kg) not only reduced the levels of ALT, AST, hyaluronic acid, laminin, procollagen III n-terminal peptide, collagen IV, MDA, TGF-β1 significantly and the degree of hepatic fibrosis, but also increased SOD activity in a CCl4-induced liver fibrosis model in rats (Wu et al., 2011).