In chronic CCl4/HFD-induced liver injury, HSYA ameliorated serum biochemical indicator, reduced mRNA expression levels of pro-fibrotic factors and elevated hepatoprotective factors, which revealing that PPAR-γ and p38 MAPK signaling play pivotal roles in the prevention of liver fibrosis (Liu et al., 2014). This evidence concerns the gene PPARG and Hepatic fibrosis.