WNT5A and hepatocellular carcinoma: Recently, researchers found that HD showed antioxidant, antiinflammatory and proapoptotic activities by significantly prevented thioacetamide-activated Wnt3a/β-catenin and Wnt5a pathways in thioacetamide-induced early HCC model in rats, which suggested that HD exhibited an antitumor and hepatoprotective effects against the development of HCC (Zaghloul et al., 2017).