This is supported by Wang et al.‘s work demonstrating that MMP-9 inhibitory activity of GEN and its inhibition of multiple signal transduction pathways such as MAPK, inhibitor of NF-κB (IκB), and phosphoinositide 3-kinase (PI3K)/Akt could control the invasiveness and metastatic potential of HCC (Wang et al., 2014). Here, AKT1 is linked to hepatocellular carcinoma.