The RYK gene was previously associated with shortened long bones in the limbs in mice (Andre et al., 2012), while FGF23 was associated with subclinical hypocalcemia in dairy cows and 1,25-Dihydroxyvitamin D synthesis (Simic and Babitt, 2021; Ma et al., 2022). The gene discussed is RYK; the disease is Hypocalcemia.