In classic RAAS system, AGT is associated with the generation of angiotensin II (Ang II), Ang II activates its Angiotensin II type 1 (AT1) receptor, the main receptor mediating vasoconstriction, aldosterone secretion, and renal sodium (Na+) re-absorption, which increased blood pressure and promoted the development of hypertension 26,27. Here, AGT is linked to hypertensive disorder.