CXCL12 and chronic kidney disease: By stratifying DKD cases into two severity groups (early CKD and pre-ESRD), we found that the correlation of SDF-1 rs1801157 with DKD was particularly detected in diabetic patients with early CKD (GA vs GG, AOR, 2.198; 95% CI, 1.036-4.663, p=0.040; GA+AA vs GG, AOR, 2.116; 95% CI, 1.029-4.353, p=0.042) in additive model and dominant model (Table 4).