The hypothesis presented here integrates three convergent lines of evidence to suggest a novel, feasible, theoretically sound, minimally invasive method – to convert a tumor that is immunoresistant to one that is immunoresponsive: i) cytokine reduction, specifically IL-6 reduction/normalization; ii) combination with ICI (PD-1/PD-L1 inhibition); and iii) vagus nerve stimulation. This evidence concerns the gene CD274 and neoplasm.