EIF3A and infection: Similarly, AAV-eIF3A infection reversed the inflammatory infiltration and inhibited crypt stem cell differentiation induced by ginger treatment; however, AAV-eIF3A (C58A) did not induce a relatively reversed effect (Fig. 7E to M), given the mutation in the binding site for 6-shogaol, making it ineffective for inhibition of eIF3A by 6-shogaol.