PGP and neuropathy: Figure 1 demonstrates the PGP 9.5 immunoreactivity in the thigh skin from all four study groups. There was a reduction in PGP immunoreactivity in the DPN groups compared with non-neuropathy groups (all; LSD, p < 0.001). However, there was no significant difference between the painless- and painful-DPN groups (p = 0.208).