CD8A and incontinentia pigmenti: Interestingly, although monofunctional responses were detected in higher frequencies, only polyfunctional CD8+ T cells significantly discriminated EBV seronegative patients from seropositive HC and IP groups (IP-SNEG 0.00% vs. IP-SPOS 0.04% and HC 0.02%; p=0.01 and p<0.001, respectively; Figure 1A).