As shown in Figure 1D, the expression of CD56 was significantly lower in EVs isolated from 17 HD (MRFI, median ± SE:4.01 ± 0.35) than in those from 29 NB patients (20 at M and 9 at L stage; 9.79 ± 2.35, p<0.0001). This evidence concerns the gene NCAM1 and neuroblastoma.