The focus of our research presented here is DYT-PRKRA [also known as dystonia 16 (DYT16)], which is an early-onset, generalized dystonia caused by variants in the PRKRA gene, which encodes the protein PACT (Patel and Sen, 1998), a stress-modulated activator of the protein kinase PKR (Patel et al., 2000). This evidence concerns the gene PRKRA and generalized dystonia.