In future studies, it will be beneficial to breed the Prkralear-5J mutation, as well as other DYT-PRKRA mutations, in a C57BL/6 genetic background, which could clarify whether the resulting dystonia phenotype arises owing to the truncated PACT/RAX protein alone or a combination of Prkralear-5J mutation and the BTBR T+Itpr3tf/J genetic background. The gene discussed is PRKRA; the disease is Dystonia.