Moreover, studies on samples from AD patients and elderly individuals who died of natural aging have shown a correlation between hyperphosphorylated tau and autophagy biomarker microtubule associated protein 1 light chain 3 (LC3) and autophagy substrate protein ubiquitin binding protein 1 (Sequestosome 1, p62) positive autophagosomes in AD patient samples (Piras et al., 2016; Uddin et al., 2019). Here, MAPT is linked to Alzheimer disease.