Therefore, in the metabolomic analysis, we sought to explore the concentrations of monoamines, glutamate and gamma-aminobutyric acid (GABA), amino acids, and some other metabolites in the brain regions associated with depression, including the PFC, Hb/PVT, hippocampus, hypothalamus, and plasma of chronic CORT- and Veh-treated mice. The gene discussed is GSTM1; the disease is major depressive disorder.