The prefrontal cortex (PFC), hippocampus, habenula (Hb), paraventricular nucleus of the thalamus (PVT), and hypothalamus (Hypo), are among the brain regions associated with depression [36–39], However, what metabolomic changes in the specific brain regions are caused by chronic CORT exposure remain unknown. Here, GSTM1 is linked to major depressive disorder.