CD274 and neoplasm: As expected, the well-established predictive biomarker tumor proportion score (TPS) of PDL-1 [30, 31] was significantly higher in patients with PR/CR as best response compared to PD in the Aachen ICI cohort (n = 51, p = 0.003, Supp.Fig. 7C), however, when applying the established cut-off of ≥ 1% [32], only a trend towards better PFS was seen (p = 0.08, Supp.Fig. 7A) and OS (Supp.Fig. 7B) was not different.