One SD higher NPX value for ACE2 in women conferred a multivariable-adjusted HR of 1.29 (95% CI 1.07–1.55) for IHD and 1.07 (95% CI 0.81–1.41) in men (p-value = 0.07 for interaction). The gene discussed is ACE2; the disease is myocardial ischemia.