SCN9A and Obesity: Under this framework, it is to be expected that genes associated with obesity—such as ELOVL2, PDGFC, SCN9A, SLC6A4, and TFEB—were found to be linked to the MOD-MRS.For example, SCN9A is known to control satiety and hunger centres in the brain, while other genes regulate fatty acid metabolism emphasising their close correlation with body weight and BMI.