Under this framework, it is to be expected that genes associated with obesity—such as ELOVL2, PDGFC, SCN9A, SLC6A4, and TFEB—were found to be linked to the MOD-MRS.For example, SCN9A is known to control satiety and hunger centres in the brain, while other genes regulate fatty acid metabolism emphasising their close correlation with body weight and BMI. Here, SCN9A is linked to obesity due to melanocortin 4 receptor deficiency.