TCF4 and liver cancer: Previous studies have shown that β-catenin engages the DNA-bound transcription factor TCF in the nucleus [47], and ENAH has been identified as a transcriptional target of the Wnt/β-catenin/TCF4 complex in liver cancer cells [19], suggesting that ENAH is upregulated via β-catenin/TCF4 binding to the ENAH promoter in OSCC.