Furthermore, TP53INP1 silencing considerably alleviated D-gal-induced cardiac hypertrophy (Fig. 8i, j), myocardial IL-1β and IL-6 levels (Fig. 8k), and β-gal-positive cells (Supplementary Fig. 18a, b) in the KO mice. The gene discussed is IL1B; the disease is cardiac hypertrophy.