SFRP4 and cancer: As presented in Fig. 1e, SFRP4 gene expression had significantly increased fold changes in stroma cancer compared to stroma non-cancer spots (log2FC = 2.098, p = 2.18 × 10−230) and in stroma HG cancer compared to stroma LG cancer spots (log2FC = 2.048, p = 5.44 × 10−175).