However, by virtue of DNAM-1 having a higher affinity to PVR than to nectin-2, it is safe to assume that NK cytotoxicity will largely depend on PVR expression level, and indeed PVR is widely expressed in human cancers.255–257 Other important activating receptors include NKp80, which binds to activation-induced C-type lectin (AICL), CD28 which binds to CD80 and CD86, CD2 which binds to CD48 (also a partner of 2B4) and CD58; the KIRs with short cytoplasmic domains, KIR-2DS and KIR-3DS, and C-type lectin receptors CD94/NKG2C, and NKG2E/H/2F. This evidence concerns the gene CD226 and cancer.