However, there are reports of conversion from a CD56dim to CD56bright phenotype under IL-12.181 Interestingly, TGFβ can convert PB CD16pos into a CD16neg decidual like NK cells,182 and NK cells exposed to TGFβ or its relative Activin, acquire a gene signature and phenotype similar to the less cytotoxic ILCs, becoming unable to control tumor growth in mice.183–185 This suggests IL-12 and TGFβ1 may be possible mechanisms for converting NK1 to an NK2-like state or NK2 to an ILC state. This evidence concerns the gene TGFB1 and neoplasm.