LAG-3 is highly expressed in T-cells from Hodgkin lymphoma and leukemia patients, and its synergy with anti-PD-1 was evident.543 In vitro, chronic stimulation of NK cells leads to epigenetic changes, upregulation of LAG-3 and PD-1, and NK cell dysfunction.544 LAG-3 mediated inhibition controls AKT phosphorylation and STAT5 activation leading to reduced mitochondria mass and quiescence.545 However, LAG-3 impact on NK cells remains obscure and needs more investigation. This evidence concerns the gene LAG3 and leukemia.