Blocking HLA-E interaction with ligand NKG2A on NK and CD8 T-cells allowed the killing of senescent cells by NK cells.387 A clear link between senescent and cancer cells was demonstrated by the reduction of spontaneous tumorigenesis and cancer-related death after the depletion of senescent cells in aging mice.388 An immediate question arises regarding why senescent cells accumulate in the elderly but not in the young. The gene discussed is CD8A; the disease is cancer.