KLRK1 and cancer: The example of NKG2D interaction with ligand RaeI revealed that this process required clathrin-dependent internalization of NKG2D, leaving RaeI on the cell surface for a period of at least 24 h.547 RaeI-dressed NK cells do not kill each other, suggesting they lost NKG2D in this process and are only killed by cells that did not interact with cancer cells.