HLA-E and cancer: Blocking HLA-E interaction with ligand NKG2A on NK and CD8 T-cells allowed the killing of senescent cells by NK cells.387 A clear link between senescent and cancer cells was demonstrated by the reduction of spontaneous tumorigenesis and cancer-related death after the depletion of senescent cells in aging mice.388 An immediate question arises regarding why senescent cells accumulate in the elderly but not in the young.