CD38 and plasma cell myeloma: Multiple myeloma expressing high levels of CD38 and targeted with anti-CD38 Daratumumab (Dara), reduces NK cell number due to ADCC-mediated fratricide.549 Knockout of CD38 in expanded primary NK cells prevented Dara-induced fratricide in NSG mice, which are devoid of NK cells.550 However, host NK cells would probably be targeted by ADCC if the patient is not lymphodepleted first.