Multiple myeloma expressing high levels of CD38 and targeted with anti-CD38 Daratumumab (Dara), reduces NK cell number due to ADCC-mediated fratricide.549 Knockout of CD38 in expanded primary NK cells prevented Dara-induced fratricide in NSG mice, which are devoid of NK cells.550 However, host NK cells would probably be targeted by ADCC if the patient is not lymphodepleted first. This evidence concerns the gene CD38 and AL amyloidosis.