IFNG and cancer: NK cells increase inflammation after activation by tumor and virus-infected cells by secreting inflammatory cytokines such as IFNγ,22,23 which activates macrophages and neutrophils,24 T-cells,25 and B-cells.26 However, cancer cells treated with IFNγ become resistant to NK cells, suggesting that NK cells secretion of IFNγ may be designed to involve other immune cells27 to remedy their deficiency, suggesting a redundancy mechanism.