CD4 and systemic lupus erythematosus: For example, in multiple sclerosis, it is thought that NK cells fail to remove myelin-reactive T-cells and fail to suppress autologous CD4 + T cells compared to healthy controls.335,336 In Systemic Lupus Erythematosus (SLE), notable reductions in peripheral NK cell number and cytotoxicity were observed.337,338 However, the role of NK in developing SLE has been established through a bidirectional interaction between NK and peripheral DCs.