TIGIT is consistently upregulated in NK cells in human primary tumors and viral infection.539 TIGIT blockade reverses the exhaustion of NK cells from colon cancer patients and promotes their antitumor responses in mouse models.524 Additionally, NK cells expressing low TIGIT are resistant to MDSCs inhibition,432 suggesting the importance of this receptor in the crosstalk within the TME. Here, TIGIT is linked to colonic neoplasm.