HBEGF and neoplasm: When stratifying EC patients based on tumor size (Fig. 6b), five proteins were significantly increased in patients with tumors larger than 2 cm: endoglin (p = 0.03), FAP (p = 0.001), HB-EGF (p = 0.04), MIA (p = 0.01), and VEGF-A (p = 0.02), when compared to patients with smaller tumors (≤ 2 cm).