Two of the main up-regulated proteins, aurora kinase B and pyrroline-5-carboxylate reductase 1/2 (PYCR1/2), are oncogenes with increased expression in multiple malignancies and associated with MYC in cancer and therefore link to the MYC target hallmarks shown in Fig 4B (Burke et al, 2020; Zhao et al, 2022). Here, PYCR1 is linked to cancer.