In fact, both their actions as dual PPAR agonists and as inhibitors of the aforementioned cholinesterase enzymes have been proven to counteract cognitive impairment in AD animal models (Aksoz, Akyol, and Korkut 2024; Sato et al. 2011; Wójtowicz et al. 2020). The gene discussed is BCHE; the disease is Alzheimer disease.