Due to the emerging role of TRPM7 in neurodegenerative diseases (Sun et al. 2015) and the recent findings of the inhibitory effect of negatively charged pCBs, in particular CBGA, on TRPM7 (Suzuki et al. 2023), we decided to investigate whether the treatment with CBGA and CBDA could also affect the expression level of Trpm7 mRNA in the hippocampus. The gene discussed is TRPM7; the disease is neurodegenerative disease.