For example, H3K9Me3 was shown to decrease E-cadherin expression and thereby promote epithelial-mesenchymal transition in lung cancer.47In colon cancer, it could silence Fas expression, inhibiting apoptosis.36In melanoma, SETDB1 activates thrombospondin-1 and is responsible for maintaining tumorigenic function,48whereas it abrogates the p53, Bak, Bax, and Bim activity in pancreatic cancer.23, 49. Here, THBS1 is linked to melanoma.