The basis of this assay relies on the simultaneous occurrence of an SNP at the IL-1A + 4845 and IL-1B + 3954 loci which result in excessive IL-β production in response to lipopolysaccharide from gram-negative periodontal pathogens.40In a similar context, LD analysis in this study showed that rs3743674 and rs5030625E-cadherinSNPs, significantly associated with periodontitis, were nonrandomly correlated with each other. This evidence concerns the gene IL1A and periodontitis.