CDH1 and Crohn disease: Similar disease mechanistic processes are proposed in patients with Crohn's disease in whichE-cadherinSNPs have identified increased epithelial permeability due to abnormal cytoplasmic accumulation and impaired cell membrane localization of E-cadherin.33Consequently, any further infection and inflammation would lead to the ingress of periodontal pathobionts into the underlying tissues, which would lead to exacerbating effects on E-cadherin levels/function and loss of epithelial phenotype via EMT.