IL1B and periapical periodontitis: To explain this occurrence, it is important to note that several cytokines, including IL-1β and IL-6, are known to play a role in the development of apical periodontitis.35IL-10, on the other hand, is an anti-inflammatory cytokine that plays an important role in the prevention of autoimmune and inflammatory diseases.45Emad et al, using polymerase chain reaction, discovered statistically substantial downregulation of IL-1β gene expression levels in all groups after 1 week, with no statistically significant difference between the cryotherapy and control groups.