Although there are no pharmacological means to elevate intracellular Mg2+ levels above-normal levels, Mg2+ deficiency can readily be treated by supplementation and therefore it would be beneficial to monitor patient Mg2+ levels to avoid dietary magnesium deficiency which is expected to worsen the impact of the LIG1 variant alleles. Here, LIG1 is linked to hyperinsulinemic hypoglycemia, familial, 4.