SPRED1 is highly expressed in the brain, and the enzyme zDHHC17 (HIP14), which is involved in the palmitoylation of mutant huntingtin (HTT), the causative gene for HD, has been reported to also be involved in the palmitoylation of Sprouty2 and SPRED3 (18). This evidence concerns the gene SPRED1 and Huntington disease.