SPRED1 is highly expressed in the brain, and the enzyme zDHHC17 (HIP14), which is involved in the palmitoylation of mutant huntingtin (HTT), the causative gene for HD, has been reported to also be involved in the palmitoylation of Sprouty2 and SPRED3 (18). The gene discussed is SPRED3; the disease is Huntington disease.