SCARB1 and Sepsis: Later studies showed that SR-BI protects against sepsis through multiple mechanisms, including prevention of nitro oxide-induced cytotoxicity (14), promotion of LPS clearance (15, 16), suppression of inflammatory signaling in macrophages (15, 17), and mediating induced glucocorticoid GC production in adrenal gland (16, 18, 19, 20, 21).