The antioxidant CoPP is known to act through Nrf2 activation to activate antioxidant defenses, particularly the expression of HO-1 (heme oxygenase-1) and was previously used by us in T. cruzi infection by Y strain in C57BL/6 mice, reducing parasitemia and macrophage parasitism [1]. The gene discussed is HMOX1; the disease is parasitic infectious disease.