Cells were transfected with vector encoding for SpCas9 either without guide RNA (SpCas9) or with guide RNA targeting EHMT1 (EH_132); 36 h post transfection, cells were infected with WT SeV and simultaneously treated with BX795; 24 h post infection, cells were harvested for RNA isolation and qRT-PCR to assess the expression of various IFNs and SeV genomic RNA. The gene discussed is EHMT1; the disease is infection.