However, CD8 T cells (p < 0.0001), naïve CD4 T cells (p < 0.01), regulatory T cells (p < 0.0001), M1 macrophages (p < 0.01), and resting dendritic cells (p < 0.001) were significantly lower in the RA group than in the normal group (Fig 7E). The gene discussed is CD4; the disease is rheumatoid arthritis.