GRIN1 and amyotrophic lateral sclerosis: As summarized in Fig 7, we demonstrated that BP can prevent or reverse neuron degeneration, reduce the overexpression of glutamate receptor subunits GluR3 and NMDAR1, inhibit excessive glutamate-induced calcium influx, and prohibit hyperactivated apoptosis signaling in motor neurons derived from ALS patient iPSCs harboring the SOD1G85R mutation.