Similar to the findings in our transcriptional analysis, we found increased TNFα (P = 0.028) and CXCL1 (P = 0.0056) in the ECRG4 KO mouse infection, as well as a trend towards increased CXCL2, IL1β, and IL6 (Fig 2D). The gene discussed is CXCL1; the disease is infection.